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diagnosis syndrome leukemia treatment workup aplastic chronic hemolytic hemophagocytic hlh hodgkins lymphocytic lymphohistiocytosis lymphoma mds myelodysplastic rheumatology activation agglutinin algorithm
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Headaches, bone pain, fever ... - infiltrates (anemia ... Lymphadenopathy • HSM • Fevers ... #Leukemia #Hematology ... #Oncology #Diagnosis
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Consider stem cell ... if neutropenic fever ... #diagnosis #management ... #treatment #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
iron deficiency anemia ... Autoimmune hemolytic anemia ... RBC: Hemoglobin SS ... RBC #Morphology #differential ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Lymphadenopathy • Fevers ... • Neutropenia, anemia ... diagnosis #workup #oncology ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Diagnosis and Management ... cytopenias (usually anemia ... Allogeneic stem cell ... #treatment #hematology ... #oncology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Consider sickle cell ... bartonella (oroya fever ... Algorithm #workup #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
immunophenotype Clinical ... ) B symptoms → fevers ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Autoimmune diseases • Clinical ... - Pel-Ebstein fever ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Lymphohistiocytosis (HLH) Clinical ... Features: Fever ... : ↑↑ ferritin, Anemia ... 8 criteria: • Fever ... Lymphohistiocytosis #diagnosis #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... : • Fever • Fatigue ... recurrent infections/fevers ... #oncology #hematology ... #diagnosis #management
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