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Idiopathic Thrombocytopenic Purpura Clinical: • Gingival • Menorrhagia • GI bleeding • Intracranial
Thrombocytopenic Purpura Clinical ... Menorrhagia • GI bleeding ... children) • Platelets ... only for severe bleeding ... extremely low platelet
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
common inherited bleeding ... disorder Clinical ... bruising • Skin bleeding ... • Prolonged bleeding ... Laboratory • Normal platelet
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Findings: • Bleeding ... organ damage Clinical ... Findings: • Bleeding ... Findings in DIC: • Platelet ... Thrombocytopenia - Platelet
HAS-BLED Score for Major Bleeding Risk of Anticoagulation in Atrial Fibrillation A clinical mnemonic to estimate the
Score for Major Bleeding ... Fibrillation A clinical ... risk of major bleeding ... risk of major bleeding ... , NSAIDs, anti-platelets
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
Helpful Clinical ... in Evaluating Bleeding ... haemophilias, bleeding ... haemorrhage or bleeding ... characteristic of platelet
Indications for tPA in Stroke: • Clinical diagnosis of ischemic stroke • Measurable neurologic deficit •
in Stroke: • Clinical ... Active internal bleeding ... > 110mmHg • Platelet
Indications for Transfusion Packed RBCs • Hgb <7 g/dL or hematocrit <21% in a patient with uncompromised
hemoglobinopathy Platelets ... • < 30,000 and bleeding ... postoperative bleeding ... < 100,000 and bleeding ... Platelet transfusions
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... Single isolated platelets ... without platelet ... failure Grey Platelet ... • Absence of platelet
Thresholds for Transfusion of Platelets in Adults Major surgery or invasive procedure, no active bleeding - ≤
Transfusion of Platelets ... procedure, no active bleeding ... neurosurgery, no active bleeding ... Surgery with active bleeding ... #Management #Platelets
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 Bleeding and Bruising - Differential Diagnosis Algorithm • Vascular System Defect - Congenital vs Acquired •
Bleeding and Bruising ... vs Acquired • Platelet ... vs Acquired #Bleeding
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