18 results
Role of Uric Acid in the Inflammation of Gout

Allopurinol, Febuxostat - Xanthine oxidase
Colchicine - Release of
Inflammation of Gout ... inflammation #gout ... #uricacid #pathophysiology ... #pharmacology # ... rheumatology
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
., IL-1, IL-2 Muromonab-CD3 ... Basiliximab - IL ... Suppression of IL ... Immunosuppressant #Drugs #Pharmacology ... #Pathophysiology
Uric Acid Homeostasis
In the liver, purines are metabolized to uric acid. The last step in purine
The gout drug pegloticase ... eliminate about 1/ ... #Homeostasis #Gout ... #Pathophysiology ... #Pharmacology #
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
trauma (> 65 years old ... disease states Pathophysiology ... arthritic flare. 1. ... to Manifest: 1. ... #Comparison #rheumatology
Causes of Interstitial Lung Disease - Differential Diagnosis Algorithm
Idiopathic Interstitial Pneumonia
 • (UIP) Usual Interstitial Pneumonia
this should be 1° ... fluid leaking out ... Chronic Radiation Pneumonitis ... Lung #Diseases #ILD
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
lasting > 30 mins - 1 ... Crystal induced (Gout ... - Autoimmune Rheumatologic ... Ankylosing Spondylitis, IBD ... Diagnosis #MSK #rheumatology
Gout - Management
Acute Gout Flare
 1) colchicine, NSAIDs, glucocorticoids
 2) Anakinra (IL-1 inhibitor)
When to Start Urate
1) colchicine, ... 2) Anakinra (IL ... -1 inhibitor) When ... Therapy (ULT) 1) ... Management #treatment #rheumatology
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... efflux increases out ... Classification: CLASS 1 ... Antiarrhythmics #Pharmacology ... Classification #Classes #pathophysiology
Attention Deficit Hyperactive Disorder (ADHD): Pathogenesis and clinical findings
 - For diagnosis, must have either 26
at > 17 years old ... than females (4:1) ... Impulsivity • Blurts out ... BehavioralDisorder #Pathophysiology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
diagnosis • Rule out ... efficacious include IL ... -1 inhibitors, IL ... inhibitors, and IL ... SAPHO #Syndrome #Rheumatology