21 results
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
cytokines, such as IL ... -1 and IL-6, leading ... Histopathologic criteria ... Diagnosis #Management #Hematology ... #Rheumatology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
5 of the below criteria ... should be major: 1. ... Minor criteria include ... Treatment - Mild ... AOSD #diagnosis #rheumatology
Attention Deficit Hyperactive Disorder (ADHD): Pathogenesis and clinical findings
 - For diagnosis, must have either 26
at > 17 years old ... than females (4:1) ... AttentionDeficitHyperactiveDisorder #ADHD #BehavioralDisorder ... #Pathophysiology ... signs #psychiatry #criteria
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
cytometry — GP Ilb ... either severe Type 1 ... or Type 3) — differentiate ... Platelet #disorders #hematology ... #hemepath #differential
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
Criteria for Diagnosis ... : 1. ... Resolution > 15 days Differentials ... withdrawal • Mild ... Severe disease: 1.
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Arterial Thrombosis - Differential ... Ischemic Liver, IBD ... Venous #Arterial #pathophysiology ... #hematology #differential
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework

Heat Cramps:
 • Muscle pain or spasm -
Heat Stroke - Differential ... Collapse: • Pathophysiology ... heat stress • Criteria ... Multi-system illness: 1. ... temperatures • Criteria
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
SLE, SjS, CTD-ILD ... phenomenon - EJ, Jo-1, ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... symptoms, or> 1 ... initiation • Differential ... diagnosis #management #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... • Acute lupus pneumonitis ... • ANA titers > 1: ... Ro/La, anti-Jo-1, ... Erythematosus #Diagnosis #Rheumatology