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diagnosis management differential hematology comparison signs symptoms table syndrome treatment causes antibody antinuclear behavioraldisorder criteria dermatology disease diseases infectiousdiseases inflammatory
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
ILD • Liver dysfunction ... ILD worsens ... prevalence of RP-ILD ... Phenotype 1 ... #rheumatology #
Nodular pattern 1. Hypersensitivity pneumonitis: ill defined centrilobular nodules. 2. Miliary TB: random nodules 3. Sarcoidosis: nodules with perilymphatic
Nodular pattern 1. ... Hypersensitivity pneumonitis ... : ill defined centrilobular ... Hypersensitivity pneumonitis ... next to pleura and
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Dermatomyositis ... holster sign, and ... Classic triad of ILD ... , myositis, and ... Myositis #diagnosis #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... dermatomyositis ... 1. ... Jcortesizaguirr #ANA ... antibodies #diagnosis #rheumatology
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis ... Antibodies: Anti-Jo-1, ... Demographics: - F:M, 2:1 ... dehydrogenase (LD ... PM #Diagnosis #Pathophysiology
Heme Synthesis Pathway Enzymes 1. ALA Synthase 2. ALA Dehydratase 3. Porphobilinogen deaminase 4. UP Ill Synthase 5. UP Ill Decarboxylase 6. Coproporphyrinogen
Pathway Enzymes 1. ... ALA Synthase 2. ... ALA Dehydratase ... UP Ill Synthase ... Synthesis #Pathway #pathophysiology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ANA ... Myositis: Anti-JO-1, ... Polymerase Ill ... Autoantibodies #Rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... Disease Associations ANA ... Drug-induced SLE Anti-Jo-1 ... Polymyositis / Dermatomyositis ... diagnosis #table #rheumatology
Hypothermia in Sepsis - Pathophysiology • 20% of septic pts → HYPOTHERMIA • Increased mortality 62%
Hypothermia in Sepsis - Pathophysiology ... insufficiency MECHANISMS: 1. ... endothelial integrity and ... -6, ↓IL-1 3. ... Hypothermia #sepsis #pathophysiology
Immune Reactions and Immunosuppressant Drugs Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2 Muromonab-CD3 - Monoclonal antibody Calcineurin
Immune Reactions and ... synthesis, e.g., IL ... -1, IL-2 Muromonab-CD3 ... Suppression of IL ... #Pharmacology #Pathophysiology
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