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diagnosis management differential autoantibodies lupus antinuclear associations comparison cppd dermatology diseases erythematosus hematology infectiousdiseases sle systemic abscess allergy anca antibody
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
ANA - Non-specific ... Drug-induced SLE Anti-Jo-1 ... #diagnosis #table ... #rheumatology # ... antibodies
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... dermatomyositis ... 1. ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... others (RNP, aPL antibodies ... Myositis: Anti-JO-1, ... Polymerase Ill ... #associations #table
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
severity of the disease ... and ILD • Liver ... ILD worsens ... Phenotype 1 ... #rheumatology #
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis ... Elevated Antinuclear Antibodies ... : Anti-Jo-1, Anti-OJ ... dehydrogenase (LD ... PM #Diagnosis #Pathophysiology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
, dermatomyositis ... • Acute lupus pneumonitis ... titers > 1:80 ... Ro/La, anti-Jo-1, ... SCL-70, RNP antibodies
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... syndromes Anti-PCNA 1- ... erythematosus #diagnosis #rheumatology ... #table #ANA
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Anti-MDA5 (RP-ILD ... ), dermato-rheumatologic ... Ab • Anti-Jo-1 ... antibodies (ANA ... enzymes • Anti-Jo-1
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Allergen-specific lgE antibodies ... during hemolytic disease ... Type Ill - IgG and ... Classification #Pathophysiology ... Diagnosis #Reactions #Table
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Epidemiology: • F > M: 9:1 ... hypofunction • Antibodies ... ≥ 1:320 • Cytopenia ... • Interstitial Pneumonitis ... Sjogrens #Syndrome #Rheumatology
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