13 results
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Anti-Jo-1 - Polymyositis ... / Dermatomyositis ... #diagnosis #table ... #rheumatology # ... antibodies
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
(MSAs) Dermatomyositis ... TIF1y, NXP2, Mi-2, SAE ... Anti-Synthetase Syndrome: Jo-1, ... clinical #diagnosis #rheumatology ... #table
Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
DM/PM : dermatomyositis ... rheumatoid arthritis SLE ... ConnectiveTissueDiseases #ILD ... Differential #Comparison #Table ... #Pulmonary #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... in drug-induced SLE ... Polymyositis and dermatomyositis ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ... others (RNP, aPL antibodies ... Myositis: Anti-JO-1, ... RNA Polymerase Ill ... #associations #table
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
, dermatomyositis ... • Acute lupus pneumonitis ... • ANA titers > 1: ... Ro/La, anti-Jo-1, ... SCL-70, RNP antibodies
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... syndromes Anti-PCNA 1- ... erythematosus #diagnosis #rheumatology ... #table #ANA
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Prognosis: Usually mild ... Evolution: Chronic disease ... #comparison #table ... #rheumatology #
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Epidemiology: • F > M: 9:1 ... overlaps with RA, SLE ... ≥ 1:320 • Cytopenia ... • Interstitial Pneumonitis ... Sjogrens #Syndrome #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Anti-MDA5 (RP-ILD ... ), dermato-rheumatologic ... Ab • Anti-Jo-1 ... enzymes • Anti-Jo-1 ... Myositis #Myopathy #rheumatology