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diagnosis management syndrome differential hematology disease neurology dermatology lung lupus pulmonary sle erythematosus hemophagocytic hlh interstitial lymphohistiocytosis nephrology summary systemic
Interstitial Lung Diseases (ILD) Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): • Hypersensitivity pneumonitis, Farmer's lung, Bird
Hypersensitivity pneumonitis ... ILD caused by inhalation ... • Radiation pneumonitis ... , Polymyositis-dermatomyositis ... differential #pulmonary #causes
ILD of Known Cause - Differential Diagnosis Exposure: • Occupational: Asbestosis, Silicosis, Hypersensitivity, Pneumonitis • Treatment Related:
ILD of Known Cause ... Hypersensitivity, Pneumonitis ... • Treatment Related ... Polymyositis, Dermatomyositis ... BrighamChiefs #ILD
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
severity of the disease ... and ILD • Liver ... increases and ILD ... Phenotype 1 ... #rheumatology #
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
erythematosus 1. ... Polymyositis and dermatomyositis ... 1. ... antibodies #diagnosis #rheumatology ... #diseases
Causes of Interstitial Lung Disease - Differential Diagnosis Algorithm Idiopathic Interstitial Pneumonia • (UIP) Usual Interstitial Pneumonia
Causes of Interstitial ... Lung Disease - ... this should be 1° ... Chronic Radiation Pneumonitis ... #ILD #Causes #Differential
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Inflammatory: • IBD ... disorders • Celiac disease ... effect following treatment ... #Hematology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
(polymyositis/Dermatomyositis ... ) AKI - Pathophysiology ... oxidative iniury Treatment ... Management #Summary #causes ... #treatment
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... cytokines (TNFa,lL1, IL6 ... • Autoimmune diseases ... Treatment: • ... #summary #rheumatology
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
• Most common cause ... Lung Abscess Pathophysiology ... : 1. ... Pneumonitis 3. ... #differential #causes
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
screening for disease ... with established disease ... may be normal in mild ... cases) • PT/INR ... #hematology
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