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diagnosis hematology antinuclear pancytopenia algorithm causes cytoplasmic management testing workup abnormal agglutinin aggregometry anemia antibodies antinxp2 antinxp2dm aptt arthritis bandemia
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... SLE, SjS, CTD-ILD ... phenomenon - EJ, Jo-1, ... #differential # ... diagnosis #rheumatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Inflammatory and ... Autoimmune Diseases ... hemoglobinuria • Antibody-mediated ... #Diagnosis #Hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibody refers ... Positive ANA ≠ Autoimmune ... : The ANA patterns ... #patterns #rheumatology ... #diagnosis #differential
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis ... Autoimmune Mediated ... Autoimmune condition ... Pancytopenia #Workup #Differential ... Diagnosis #Algorithm #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis ... Autoimmune Mediated ... Autoimmune condition ... Pancytopenia #Workup #Differential ... Diagnosis #Algorithm #Hematology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Atypical HUS, autoimmune ... glomerulonephritis, type 1 ... Ann Marie Kumfer ... Mnemonic #diagnosis #differential ... #hematology
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
anti-Mi-2, anti-TIF-1, ... exclusion Necrotizing Autoimmune ... : Proximal and distal ... Inflammatory #Myopathies #differential ... diagnosis #comparison #rheumatology
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... SLE, SjS, CTD-ILD ... phenomenon • EJ, Jo-1, ... #differential # ... diagnosis #rheumatology
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
similar aggregation pattern ... cytometry — GP Ilb ... agonists • This pattern ... either severe Type 1 ... Platelet #disorders #hematology
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
Microangiopathy - TMAs 1. ... drug-associated TMA (antibody ... metabolism and ... . 5. 2nd TMA- autoimmune ... Microangiopathy #TMAs #hematology
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