1130 results
Schizophrenia: Pathogenesis and Symptoms
Increased dopaminergic transmission in mesolimbic projection
-> Dopaminergic neurons here project into the limbic
Pathogenesis and Symptoms ... in mesolimbic projection ... cause the Positive Symptoms ... in mesocortical projection ... decision-making, language production
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
(SLE) Signs / Symptoms ... Decreased tear production ... Decreased saliva production ... Decreased sebum production ... Diagnosis #Signs #Symptoms
Lung Abscess
Microbiology:
 • Polymicrobial 
 • Anaerobes (most common) 
Clinical: 
 • Indolent symptoms that evolve
• Indolent symptoms ... cough, sputum production
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings

 • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
Estrogen) • Inhibit production ... Osteoclasts • Inhibit production ... pathophysiology #signs #symptoms
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
hepatocellular aerobic ATP production ... increased lactate production ... also includes symptoms
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
to excess TSH production ... Signs/Symptoms:
Osteoarthritis (OA): Clinical findings
 • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
enzymes, joint fluid production ... diagnosis #signs #symptoms
Venn Diagram - Does this patient have pneumonia?
Diagnosis is generally based on three lines of evidence:
- Pulmonary symptoms ... cough, sputum production
Myoedema in Hypothyroidism on Physical Exam

Hypothyroidism is a clinical syndrome resulting from the production, secretion or
resulting from the production ... varied clinical symptoms ... There are several symptoms
Allergic Bronchopulmonary Aspergillosis (ABPA)
WHAT IS IT?
Hypersensitivity response to Aspergillus fumigatus in the airways
 • Primarily affects
increased mucus production ... ARE THE CLINICAL SYMPTOMS ... Increased cough or production