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diagnosis clinical sign physicalexam symptoms video pocus pathophysiology cardiology differential radiology neurology management pulmonary ultrasound algorithm msk pediatrics endocrinology orthopedics
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
Amyloid precursor protein ... amyloid precursor protein ... chromosome 21) Signs ... geriatrics #diagnosis #signs
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Chiari Syndrome - Protein-Losing ... pathophysiology #signs
Muehrcke's Lines (Leukonychia striata) Narrow while transverse lines (Not depressed, compared to Beau's lines). Usually 2 or
states of decreased protein ... synthesis or increase protein ... Clinical #Photo #Sign
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings The epidemiology of this disease is 1/340,000 births and roughly double
Signs of immunodeficiency ... signal transduction protein ... immunoglobulin proteins ... humoral immunity Signs
Amyloidosis Diagnosis 1) Patient presentation • Cardiac-specific signs of amyloidosis: Diastolic heart failure, Heart failure with preserved
Cardiac-specific signs ... • Noncardiac signs ... cardiac-specific signs ... For noncardiac signs ... of monoclonal protein
Acute Rheumatic Fever: Pathogenesis and Clinical Findings Delayed autoimmune reaction -> Molecular mimicry -> GAS antigen cross-reacts with host ->
myosin and cardiac proteins ... pathophysiology #diagnosis #signs
Diagnostic Testing for Meningitis History: • Triad: Fever, neck stiffness, and altered mental status • Sens: 44%
Non-specific Kernig Sign ... 95% Brudzinski Sign ... Glucose, WBC, protein
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
gene expression/protein ... activates lipolysis Signs
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
significant portal HTN Signs ... HTN: • Ascites protein ... obstruction) • Lack of signs
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
- Mutations in proteins ... improperly folded proteins ... of UMN and LMN signs ... of UMN and LMN signs ... EMG: LMN Signs in
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