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hematology differential causes clinical pocus embolism interpretation intransit laboratory pathophysiology abnormal anticoagulation aptt cascade dic disseminated echocardiogram intravascular mcconnells models
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Intravascular Coagulation ... platelet aggregation PT ... using INR use PT ... to form clots, ... ISTH #Scoring #diagnosis
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... at the site of injury ... #Coagulation #Cascade ... #clot #PT #PTT ... #diagnosis #models
Cool echo - RV strain, McConnell sign, and CLOT IN TRANSIT!! BP is normal and pt
McConnell sign, and CLOT ... is normal and pt ... Echocardiogram #A4C ... Pulmonary #Embolism #Thrombus ... #Clots #InTransit
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 This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
What's the diagnosis ... Thrombus in transit ... Pt had extensive ... Echocardiogram #A4C ... #Clots #InTransit
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 Effect of Anticoagulants on Coagulation Tests PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Anticoagulants on Coagulation ... Tests PT / INR, ... Clotting Time, Thrombin ... Anticoagulation #Testing #Diagnosis
Thromboelastogram Interpretation Reaction Time (R Value): - Time till initiation of fibrin clot - Treatment: FFP, protamine K
initiation of fibrin clot ... achieve 20 mm clot ... assay representing thrombin-platelet ... Thromboelastography #diagnosis ... #coagulation #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... significant fibrin clot ... #diagnosis #causes
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Congenital intrinsic coagulation ... drugs e.g. direct thrombin ... intravascular coagulation ... Prolonged #Causes #diagnosis ... differential #hematology #coagulation
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
- Differential Diagnosis ... Retained blood clots ... or percreta) Thrombin ... intravascular coagulation ... #Differential #Diagnosis
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... for a Prolonged PT ... drugs (e.g. direct thrombin ... Prolonged #Causes #diagnosis ... differential #hematology #coagulation
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