11 results
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
Intravascular Coagulation ... platelet aggregation PT ... consumption of coagulation ... using INR use PT ... Scoring #diagnosis #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... at the site of injury ... #Coagulation #Cascade ... #clot #PT #PTT ... diagnosis #models #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Congenital intrinsic coagulation ... drugs e.g. direct thrombin ... intravascular coagulation ... #differential #hematology ... #coagulation
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
Thrombus in transit ... Pt had extensive ... Clinical #POCUS #Echocardiogram ... #A4C #McConnells ... PulmonaryEmbolism #Thrombus
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... • Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... treatment #management #hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the PT ... drugs (e.g. direct thrombin ... #differential #hematology ... #coagulation
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
- Aortic mural thrombus ... Left ventricular thrombus ... intravascular coagulation ... Vasculitis • Injury ... pathophysiology #hematology
Cool echo - RV strain, McConnell sign, and CLOT IN TRANSIT!! BP is normal and pt
is normal and pt ... Clinical #POCUS #Echocardiogram ... #A4C #McConnells ... Pulmonary #Embolism #Thrombus
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor of a coagulation ... == NORMAL PT ... intravascular coagulation ... warfarin, direct thrombin ... Differential #Diagnosis #Hematology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
ALF): • Liver injury ... hepatocellular injury ... • Albumin • Coagulation ... factors: PT/INR ... #differential #Hepatology