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diagnosis coagulation differential aptt causes prolonged clinical clots dic disseminated echocardiogram intransit intravascular mcconnells pocus ptt sign anticoagulant anticoagulation apixaban
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
Thrombus in transit ... Pt had extensive ... 3 d later with normal ... LV and RV function ... Echocardiogram #A4C
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 How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
to Evaluate an Abnormal ... Step 1: Is the PT ... Heparin, or Direct Thrombin ... Prolonging the PT ... prolonged #diagnosis #hematology
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
• Elevation in thrombin ... platelet aggregation PT ... can accelerate thrombin ... using INR use PT ... Scoring #diagnosis #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
FVa to generate thrombin ... Thrombin, then primes ... and endothelial cells ... #clot #PT #PTT ... diagnosis #models #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... PT/NORMAL PTT: ... PT/ABNORMAL PTT ... warfarin, direct thrombin
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the PT ... drugs (e.g. direct thrombin ... amyloidosis #Abnormal ... #differential #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... drugs e.g. direct thrombin ... Jcortesizaguirr #Abnormal ... #differential #hematology
Cool echo - RV strain, McConnell sign, and CLOT IN TRANSIT!! BP is normal and pt
BP is normal and ... pt not in distress ... Echocardiogram #A4C ... Pulmonary #Embolism #Thrombus
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 Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Schistocytes, helmet cells ... treatment #management #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
- If both are normal ... Coagulation factors: PT ... of ALP • Near normal ... intestines, White blood cells ... #differential #Hepatology
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