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diagnosis coagulation abnormal aptt differential management prolonged blood clinical echocardiogram pocus product ptt reactions 2chamber a2c anatomy anticoagulant anticoagulation apical
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
Thrombus in transit ... Pt had extensive ... later with normal LV ... Echocardiogram #A4C ... PulmonaryEmbolism #Thrombus
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 How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Step 1: Is the PT ... Heparin, or Direct Thrombin ... Prolonging the PT ... to identify the cause ... prolonged #diagnosis #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the PT ... Causes include : ... drugs (e.g. direct thrombin ... #differential #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
FVa to generate thrombin ... Thrombin, then primes ... and endothelial cells ... #clot #PT #PTT ... diagnosis #models #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... drugs e.g. direct thrombin ... aPTT #Prolonged #Causes ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Treat primary cause ... treatment #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
== NORMAL PT ... level NORMAL PT ... discern these causes ... warfarin, direct thrombin ... Differential #Diagnosis #Hematology
Apical 2-Chamber (A2C) Window on POCUS Echocardiogram Helpful to distinguish anterior and inferior regional wall motion abnormalities.
Apical 2-Chamber (A2C ... for associated LV ... thrombus. ... In this case, severely ... visible mural thrombus
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 Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... potassium from lysed cells ... RBCs (stored at 4C ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... TRALI): Leading cause ... potassium from lysed cells ... RBCs (stored at 4C ... diagnosis #management #hematology
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