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diagnosis prolonged abnormal dic intravascular pathophysiology algorithm anticoagulant anticoagulation apixaban arterial bleeding bruising cascade clot dabigatran disorders edoxaban embolism emergencies
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PTT, Normal PT ... #INR #Differential ... Diagnosis #Algorithm #Causes ... #Hematology #coagulation
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Scoring System for Disseminated ... platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... Scoring #diagnosis #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and the aPTT ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... hematology #coagulation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... drugs e.g. direct thrombin ... Disseminated intravascular ... #differential # ... hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... INR < 2.3 - APTT ... treatment #management #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... and endothelial cells ... #Coagulation #Cascade ... #clot #PT #PTT ... diagnosis #models #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... liver failure, disseminated ... discern these causes ... warfarin, direct thrombin ... #Diagnosis #Hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
thrombocytopenia - Disseminated ... intravascular coagulation ... and other causes ... pathophysiology #hematology ... #differential #
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
syndrome): - Hematologic ... first) DIC (disseminated ... intravascular coagulation ... Treat underlying cause ... “big & sticky” cells
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