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diagnosis hematology abnormal dic prolonged algorithm arterial blanching bleeding bruise bruising ecchymosis embolism emergencies hematomas hemeonc hemorrhage hemostasis isth laboratory
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Scoring System for Disseminated ... Intravascular Coagulation ... , aPTT: • Expected ... using INR use PT ... #Intravascular
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... drugs e.g. direct thrombin ... Disseminated intravascular ... #differential #
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... #Intravascular
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and the aPTT ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... liver failure, disseminated ... intravascular coagulation ... discern these causes ... warfarin, direct thrombin
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... Hemorrhage - Differential ... or percreta) Thrombin ... HELLP syndrome • Disseminated ... intravascular coagulation
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Arterial Thrombosis - Differential ... thrombocytopenia - Disseminated ... intravascular coagulation ... and other causes ... pathophysiology #hematology #differential
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
ecchymosis) is caused ... are typical of coagulation ... in endothelial cells ... to be normal, PT ... VWF:RCo/VWF:Ag (differentiate
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
fever: - Fever + ANC ... first) DIC (disseminated ... intravascular coagulation ... Treat underlying cause ... “big & sticky” cells
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