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hematology algorithm bruising prolonged aptt bleeding dic intravascular petechiae purpura thrombocytopenia arterial blanching bruise chemistry dermatology disorders ecchymosis embolism emergencies
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Scoring System for Disseminated ... platelet aggregation PT ... using INR use PT ... vessels #DIC #Disseminated ... ISTH #Scoring #diagnosis
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... #INR #Differential ... #Diagnosis #Algorithm ... #Causes #Hematology ... #coagulation #disorders
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... drugs (e.g. direct thrombin ... amyloidosis #Abnormal ... #Causes #diagnosis ... hematology #coagulation
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... / Bruising - Differential ... Diagnosis Algorithm ... Destruction • Abnormal ... Deficiency • Disseminated
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... drugs e.g. direct thrombin ... Disseminated intravascular ... #Causes #diagnosis ... #differential #
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... #diagnosis #causes
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... Diagnosis Algorithm ... succenturiate lobe • Abnormal ... or percreta) Thrombin ... HELLP syndrome • Disseminated
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... PT/NORMAL PTT: ... PT/ABNORMAL PTT ... discern these causes
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Arterial Thrombosis - Differential ... Diagnosis Framework ... thrombocytopenia - Disseminated ... intravascular coagulation ... and other causes
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Rash - Differential ... Diagnosis Algorithm ... Meningococcemia - Disseminated ... Complete blood count coagulation
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