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hematology coagulation causes differential prolonged clinical clots dic disseminated echocardiogram intravascular mcconnells pocus ptt sign anticoagulant anticoagulation apixaban bleeding bruising
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
to Evaluate an Abnormal ... the PT or APTT ... Heparin, or Direct Thrombin ... Prolonging the PT ... #diagnosis #hematology
Coagulation Cascade Mnemonic - PITT vs PET PITT (with an I) = Intrinsic = APTT
Coagulation Cascade ... (with an I) = Intrinsic ... = APTT Factors ... E)= Extrinsic=PT ... Mnemonic #PITT #PET #diagnosis
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
What's the diagnosis ... Thrombus in transit ... Pt had extensive ... 3 d later with normal ... Echocardiogram #A4C
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 The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation cascade ... along with FXIIa (intrinsic ... #Coagulation #Cascade ... #clot #PT #PTT ... #diagnosis #models
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... Congenital intrinsic ... drugs e.g. direct thrombin ... #PT #aPTT #Prolonged ... #Causes #diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... integrity Clotting cascade ... PT/ABNORMAL PTT ... PT/NORMAL PTT: ... PT/ABNORMAL PTT
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and the aPTT ... affected in the intrinsic ... drugs (e.g. direct thrombin ... amyloidosis #Abnormal ... #PT #aPTT #Prolonged
Cool echo - RV strain, McConnell sign, and CLOT IN TRANSIT!! BP is normal and pt
BP is normal and ... pt not in distress ... Echocardiogram #A4C ... Pulmonary #Embolism #Thrombus ... #Clots #InTransit
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 ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
• Elevation in thrombin ... platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... INR < 2.3 - APTT ... #Coagulation #diagnosis
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