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coagulation differential abnormal prolonged dic disseminated pathophysiology ptt anticoagulant anticoagulation apixaban arterial bleeding bruising cascade clot dabigatran edoxaban evaluation hemostasis
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Step 1: Is the PT ... Heparin, or Direct Thrombin ... to identify the cause ... #prolonged #diagnosis ... #hematology #evaluation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... Congenital intrinsic ... drugs e.g. direct thrombin ... #Causes #diagnosis ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and the aPTT ... affected in the intrinsic ... drugs (e.g. direct thrombin ... #Causes #diagnosis ... #differential #hematology
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
for Disseminated Intravascular ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis ... #hematology #laboratory
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Differential Diagnosis ... - Disseminated intravascular ... coagulation and other causes ... pathophysiology #hematology ... #differential #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Increased thrombin ... INR < 2.3 - APTT ... #Coagulation #diagnosis ... #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... , disseminated intravascular ... discern these causes ... warfarin, direct thrombin ... #Hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
along with FXIIa (intrinsic ... Thrombin, then primes ... #clot #PT #PTT ... #diagnosis #models ... #hematology #pathophysiology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity is the diagnostic ... be performed PT ... , PTT, and fibrinogen ... reflection of intravascular ... #Workup #Hematology
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