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diagnosis hematology management hemophagocytic hlh lymphohistiocytosis thrombocytopenia vasculitis bradi bradycardia bruising cardiology classification erythematosus framework gravis hemeonc idiopathic lupus lymphocytopenia
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
• Autoimmune ... (Sjogren, SLE, Kikuchi ... chemotherapy) • Genetic syndromes ... #Differential # ... Causes #lymphocytopenia
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... Viral: HIV, HCV, EBV ... : ITP, HITT - Autoimmune ... : SLE, RA, antiphospholipid ... syndrome - Pregnancy
Bradycardia - Differential Diagnosis Framework BRADI Mnemonic • BRASH/Hyperkalemia • Reduced oxygen/Glucose/Temp • ACS • Drugs •
Bradycardia - Differential ... • Drugs • ICP ... Trichinosis Autoimmune ... : • SLE • Scleroderma ... #diagnosis #causes
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... disease • Non-autoimmune ... rheumatologic diseases ... deficiencies • Autoimmune ... La, anti-Jo-1, SCL
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... solid cancers • Autoimmune ... diseases: SLE++ ... of emergency, ICU ... treatment #summary #rheumatology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis is an autoimmune ... Hodgkin lymphoma - Autoimmune ... rheumatoid arthritis, SLE ... life-threatening Differential ... : - Bedside: ice
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... thrombocytopenia) - SLE ... Purpura #Bruising #Causes ... #peds #pediatrics ... #diagnosis #differential
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitides - Differential ... tract, and often causes ... mucositis - Rash ... vasculitis, and SLE ... #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... diseases, such as SLE ... , mucositis • Rash ... tract, and often causes ... #Diagnosis #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... Symptoms: • Gottron rash ... • ANA < 20 % IBM ... statins - probably caused ... #differential #
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