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diagnosis hematology agglutinin bruising cold disease erythematosus gap globulin hemeonc hemolytic hemophagocytic hlh icl idiopathic lupus lymphocytopenia lymphohistiocytosis lymphopenia management
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
- Differential ... neutropenia, Kostmann syndrome ... Chediak-Higashi syndrome ... Megaloblastic anemia-rare ... #hematology
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
• Autoimmune ... chemotherapy) • Genetic syndromes ... EBV. CMV. ... #Differential # ... Causes #lymphocytopenia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral infection, autoimmune ... hemolysis • C3↓ C4 ... - Mycoplasma, EBV ... younger pts) Differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... disease • Non-autoimmune ... rheumatologic diseases ... deficiencies • Autoimmune ... lymphopenia, low PLT • Anemia
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... erythematosus) - Alloimmune ... Purpura #Bruising #Causes ... #peds #pediatrics ... #diagnosis #differential
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... acute HIV, HBV, EBV ... Cirrhosis, ETOH, autoimmune ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... Symptoms: • Gottron rash ... • ANA < 20 % IBM ... statins - probably caused ... #differential #
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
caused by uncontrolled ... Infections (e.g., EBV ... Malignancies ▪ Autoimmune ... - Cytopenias (anemia ... of NK cells and CD8
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