19 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... • Limited to Kidney ... Glomerulonephritis #Vasculitis ... #differential #diagnosis ... #algorithm #rheumatology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Acute Kidney Injury ... - Differential Diagnosis ... Emboli, Thrombosis, Vasculitis ... GN: ANCA, Anti-GBM ... #nephrology #causes
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... Polyarteritis Nodosa: - Kidneys ... mucositis - Rash ... Kidneys -> glomerulonephritis ... #rheumatology #
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
Acute Kidney Injury ... - Small vessel vasculitis ... tubular necrosis (causes ... : sepsis, meds, ... Classification #diagnosis
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Anti-LKM (liver kidney ... disease c-ANCA - Vasculitis ... Celiac disease Anti-GBM ... Associations #diseases #diagnosis ... #table #rheumatology
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
- Differential Diagnosis ... Infectious: Influenza, EBV ... Bacteremia, Sepsis • Kidneys ... PMR, RA, SLE, Vasculitis ... #causes #neurology
Kawasaki Disease (KD) - Diagnosis and Management Summary

Kawasaki Disease (KD) is the most common vasculitis of
the most common vasculitis ... Conjunctivitis, Mucositis, Rash ... , Cough • +/-Nausea ... Polymorphous rash ... #rheumatology #
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Maculopapular rash ... Differential Diagnosis ... #dermatology #rash ... #diagnosis #rheumatology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... and Differential Diagnosis ... osmolarity If cause ... Glomerulonephritis / Vasculits ... ANCA, ANA, Anti-GBM
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANCA-Associated Vasculitis ... Renal-limited vasculitis ... + 90% • Anti-GBM ... Antineutrophil #antibodies #diagnosis ... #rheumatology #