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diagnosis rheumatology lupus differential pediatrics syndrome systemic vasculitis activation antinxp2 antinxp2dm bruising cardiology cardiomyopathy cerebritis classification cns comparison dermatology dermatomyositis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Manifestations: Malar rash ... Positive in 60-80% of cases ... life-threatening • Treatment ... : Chronic disease
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... Systemic Lupus Erythematosus ... Manifestations: Malar rash ... Usual therapeutic management ... : Chronic disease
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
(SLE) Clinical ... Cerebrovascular Disease ... autoantibodies that will cause ... cerebritis #diagnosis #management ... #treatment
Streptococcal Toxic Shock Syndrome (STSS) Complication of invasive GAS disease characterized by shock & MOF → occurs
of invasive GAS disease ... GAS in 30% of cases ... coagulopathy, erythematous ... macular rash, soft ... #management #diagnosis
Kawasaki Disease (KD) - Diagnosis and Management Summary Kawasaki Disease (KD) is the most common vasculitis of
Conjunctivitis, Mucositis, Rash ... , Cough • +/-Nausea ... Polymorphous rash ... #rheumatology #pediatrics ... #treatment
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Systemic lupus erythematosus ... Petechial or purpuric rash ... [SLE], AOSD) • ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... mucositis - Rash ... systemic lupus erythematosus ... testes -> pain, infarct ... vasculitis, and SLE
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... thrombocytopenia) - SLE ... systemic lupus erythematosus ... Congenital heart disease ... #peds #pediatrics
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
exclude other causes ... Valvular heart disease ... orthopnea, PND, LE ... teratogenic GDMT meds ... #cardiology #treatment
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
rash on the face ... Muscle atrophy may cause ... had more severe disease ... positive patients Treatment ... Dermatomyositis #diagnosis #management
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