15 results
Shock - Pathophysiology 
Inadequate tissue perfusion to meet O2, nutrient requirements
1. Distributive Shock
2. Hypovolemic Shock
3. Cardiogenic
Shock - Pathophysiology ... Hypovolemic Shock ... #Shock #Pathophysiology ... differential #diagnosis #algorithm ... #causes
Shock Classification Types - Pathophysiology Comparison

Obstructive Shock:
 • Obstructive shock is characterized by a blockage in
Shock Classification ... Types - Pathophysiology ... in blood flow caused ... Depends on the cause ... #Shock #Types #Pathophysiology
Shock - Differential Diagnosis by Classification

Hypovolemic (Intravascular volume depletion)
 - Hemorrhagic 
   • Trauma
Shock - Differential ... Diagnosis by Classification ... exacerbation (any cause ... Differential #Diagnosis #Classification ... #Table #CriticalCare
Shock - Differential Diagnosis by Classification
Reflex Syncope 
 - Vasovagal syncope
   • Prolonged standing
Shock - Differential ... Diagnosis by Classification ... bradycardia • Sinus pauses ... Differential #Diagnosis #Classification ... #Table #Causes
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
to complement activation ... Complement activation ... Hypersensitivity #Types #Classification ... #Pathophysiology ... Diagnosis #Reactions #Table
SEPSIS AND SEPTIC SHOCK

DEFINITION AND PATHOPHYSIOLOGY
 • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
DEFINITION AND PATHOPHYSIOLOGY ... • Pathophysiology ... • 49 million cases ... cytokines, complement activation ... COMMON CAUSES +
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... Allergen-specific lgE causes ... to complement activation ... types #allergy #table ... #classification
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... sequestration and activation ... without other cause ... transfusion • Pathophysiology ... diagnosis #comparison #table
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
Vaughan Williams Classification ... Inhibit B.adrenergic activation ... #Pharmacology #Classification ... #Classes #pathophysiology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Caused by splanchnic ... Pathophysiology: ... sympathetic + ADH activation ... Exclude other AKI causes ... Classification: