485 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... bilirubin • ↑ Reticulocytes ... Anemias (AIHAs) ... Anemias (AHAs)
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing in Hemolytic ... Anemia Intravascular ... Extravascular Hemolysis ... Reticulocytes ... #Anemia #Laboratory
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Antibody Autoimmune Hemolytic ... Anemia 1) DIAGNOSE ... AIHA • Anemia ... normocytic, ↑ reticulocytes ... • Hemolysis:
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Reticulocyte Production ... days) it takes a reticulocyte ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... EricsMedicalLectures/ #Reticulocyte
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Reticulocyte count ... acute blood loss, hemolysis ... for degree of anemia ... thecurbsiders podcast #Anemia
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Iron-deficiency anemia ... Sideroblastic anemia ... syndrome, Increased reticulocyte ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
of macrocytic anemia ... peripheral smear, a reticulocyte ... Hemorrhage or hemolysis ... elevated, but anemia ... megaloblastic anemia
General Approach to Anemia - Differential Diagnosis Framework
1) Check reticulocyte count to determine if hypo/hyper-proliferative
2) Exclude
General Approach to Anemia ... Framework 1) Check reticulocyte ... hyper-proliferative 2) Exclude hemolysis ... uw_IMresidency #anemia ... hematology #algorithm #reticulocyte
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Defects: Sickle cell anemia ... abnormal RBCs - Reticulocyte ... Urobilinogen #Hemolysis
Calculating a Reticulocyte Index (RI)
Reticulocyte Index = Absolute Reticulocyte Count / Maturation Correction
Absolute Reticulocyte Count =
Calculating a Reticulocyte ... Index (RI) Reticulocyte ... Index = Absolute Reticulocyte ... Count = % of reticulocytes ... hematology #diagnosis #anemia