2040 results
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
normocytic, ↑ reticulocytes ... type ± C3d • Blood ... diagnosis #management #treatment
Calculating a Reticulocyte Index (RI)
Reticulocyte Index = Absolute Reticulocyte Count / Maturation Correction
Absolute Reticulocyte Count =
Calculating a Reticulocyte ... Index (RI) Reticulocyte ... Index = Absolute Reticulocyte ... Count = % of reticulocytes ... SatyaPatelMD #Reticulocyte
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Reticulocyte count ... in peripheral blood ... High in acute blood ... Corrected reticulocyte ... count OR reticulocyte
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
WBC • ↓ PLT • Reticulocyte ... aplastic anemia Treatment ... result from low blood
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
peripheral smear, reticulocyte ... Production (↓ reticulocytes ... (hemolysis, ↑ reticulocytes
Polychromatophilia - Note 2 large blue-gray erythrocytes as seen on H&E stain. On a stain for
On a stain for reticulocytes ... The reticulocyte ... nucleated red blood ... Path #BloodSmear #Blood
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
labs: CBC, BMP, Reticulocytes ... schistocytes > 1% • ↑ Reticulocyte
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Reticulocyte Production ... days) it takes a reticulocyte ... the peripheral blood ... including chronic blood ... > 3: • Acute blood
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
(RBC = red blood ... peripheral smear, a reticulocyte ... specifically order a reticulocyte ... likely cause if the reticulocyte ... elevation in the reticulocyte
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm Blood ... of: Decreased Reticulocytes ... Normal / Decreased Reticulocytes ... Destruction - Increased Reticulocytes