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Polychromatophilia - Note 2 large blue-gray erythrocytes as seen on H&E stain. On a stain for
On a stain for reticulocytes ... The reticulocyte ... nucleated red blood ... Clinical #Path #BloodSmear ... #Blood #Smear #
Nucleated red blood cells, aka normoblasts or erythroblasts, were released prematurely from the bone marrow in
Nucleated red blood ... orthochromic normoblast – reticulocyte ... #Path #Peds #BloodSmear ... #Blood #Smear #
Calculating a Reticulocyte Index (RI)
Reticulocyte Index = Absolute Reticulocyte Count / Maturation Correction
Absolute Reticulocyte Count =
Calculating a Reticulocyte ... Index (RI) Reticulocyte ... Index = Absolute Reticulocyte ... Count = % of reticulocytes ... SatyaPatelMD #Reticulocyte
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Reticulocyte count ... in peripheral blood ... High in acute blood ... Corrected reticulocyte ... count OR reticulocyte
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
peripheral smear, reticulocyte ... Production (↓ reticulocytes ... (hemolysis, ↑ reticulocytes
Post-splenectomy blood smear demonstrating Howell-Jolly bodies and target cells.

#Clinical #Pathology #BloodSmear #HowellJollyBodies #TargetCells #Splenectomy #Asplenic
Post-splenectomy blood ... Clinical #Pathology #BloodSmear
Peripheral Blood shows a subset of atypical lymphocytes with hairy-like cytoplasmic projection.
#Clinical #Path #BloodSmear #Blood #Smear
Peripheral Blood ... Clinical #Path #BloodSmear ... #Blood #Smear #
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
labs: CBC, BMP, Reticulocytes ... schistocytes > 1% • ↑ Reticulocyte
A normal peripheral blood smear indicates the appropriate appearance of red blood cells, with a zone
normal peripheral blood ... appearance of red blood ... PeripheralBloodSmear #BloodSmear
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Reticulocyte Production ... days) it takes a reticulocyte ... the peripheral blood ... including chronic blood ... > 3: • Acute blood