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Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing in Hemolytic ... Extravascular Hemolysis ... Reticulocytes ... Carboxyhemoglobin #Hemolytic ... diagnosis #hematology #hemolysis
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... of anemia and hemolysis ... bilirubin • ↑ Reticulocytes ... Immune-mediated Hemolysis ... • Autoimmune Hemolytic
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
peripheral smear, reticulocyte ... Production (↓ reticulocytes ... ↑ Destruction (hemolysis ... , ↑ reticulocytes
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Antibody Autoimmune Hemolytic ... normocytic, ↑ reticulocytes ... • Hemolysis: ... Antibody #Autoimmune #Hemolytic
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Reticulocyte count ... percentage of reticulocytes ... acute blood loss, hemolysis ... Corrected reticulocyte ... count OR reticulocyte
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Reticulocyte Production ... days) it takes a reticulocyte ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... EricsMedicalLectures/ #Reticulocyte
Isolated Hyperbilirubinemia - Differential Diagnosis Algorithm
Direct Hyperbilirubinemia: Dubin-Johnson Syndrome, Rotor Syndrome
Indirect Hyperbilirubinemia: 
 - Trauma, Hematoma,
, Haptoglobin, Reticulocyte ... , Haptoglobin, Reticulocyte ... Count Abnormal: Hemolysis
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
peripheral smear, a reticulocyte ... specifically order a reticulocyte ... Hemorrhage or hemolysis ... likely cause if the reticulocyte ... elevation in the reticulocyte
General Approach to Anemia - Differential Diagnosis Framework
1) Check reticulocyte count to determine if hypo/hyper-proliferative
2) Exclude
Framework 1) Check reticulocyte ... hyper-proliferative 2) Exclude hemolysis ... hematology #algorithm #reticulocyte
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
syndrome, Increased reticulocyte ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic