130 results
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Decreased RBC ... Anemia of Chronic Disease ... Infiltration Increased RBC ... Thalassemia • RBC ... Disorder • RBC
Pathophysiology of Hemolytic Anemia
 - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects)
 -
Pathophysiology ... - Defects in RBC ... - Defects in RBC ... environment #Pathophysiology ... Hemolytic #Anemia #hematology
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases

Acanthocyte (spur cell),  
Basophilic stippling, 
Bite cell,
Red Blood Cell (RBC ... and Associated Diseases ... cell, Other RBC ... Howell-Jolly bodies #RBC ... #Diagnosis #Dyspmorphic
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell (RBC ... Morphology Microcytic RBC ... Target Cell RBC ... #differential #diagnosis ... #hematology #microscopy
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
- Differential Diagnosis ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... 2) External (RBC ... , Drugs, Liver Disease ... 3) Internal (RBC ... #hematology
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
- Pathophysiology ... shape, HbS induces RBC ... This leads to RBC ... #Pathophysiology ... Complications #Hematology
Common RBC Inclusions and Associations
 • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia
 • Heinz
Common RBC Inclusions ... : Hemoglobin H disease ... Sickle cell, MDS #RBC ... Inclusions #Bodies #diagnosis ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... #Differential #Diagnosis ... Algorithm #workup #hematology
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
== Decreased RBC ... Glucose Content • RBC ... Reduction == Increase RBC ... End-stage renal disease ... Dilutional Effect • RBC