60 results
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
CV/Resp/Heme: CHF ... ILD, OSA, pHTN, Anemia ... Myopathy: Drugs (statin ... Rhabdomyolysis, Critical ... #causes #neurology
Aortitis - Diagnosis and Workup
Clinical History:
 - Fever, weight loss, deterioration of general health
 - Aortic
Aortitis - Diagnosis ... and Workup Clinical ... hypertension) - Symptoms ... Infections: Syphilis ... Nivolumab, GM-CSF
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
procedures - Infection ... pylori test (GI symptoms ... changes), high MCV anemia ... candidate) - Bone ... #Causes #Workup
Anaplasma Infection - Anaplasma phagocytophilum
Pathophysiology: 
 • Obligate, intracellular bacteria
 • Transmitted via blacklegged tick —
Anaplasma Infection ... morulae Signs and symptoms ... malaise, myalgias, shaking ... immature forms) • Anemia ... #diagnosis #microbiology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
- Differential Diagnosis ... cells per μL • Diagnosis ... should be based on clinical ... Demyelinating disease caused ... #differential #diagnosis
Neurological Manifestations of Tuberculosis
Spinal Arachnoiditis & Polyradiculopathy:
 • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
4 weeks after starting ... • Caused by immune ... and not direct infection ... due to increased CSF ... #Tuberculosis #diagnosis
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Clinical Presentation ... and petechiae Causes ... Idiopathic • Infections ... • Improve the symptoms ... oncology #hematology #diagnosis
Major neurocognitive disorders (MNCD): Diagnosis and workup 

1) Clinical diagnosis Cognitive impairment + loss of autonomy
2)
1) Clinical diagnosis ... laboratory tests + imaging ... Alzheimer - 1st cause ... - Progressive amnesia ... Dementia - 2nd cause
Fever of Unknown Origin (FUO) - Further Workup

 • CNS symptoms? Get an LP and imaging
• CNS symptoms ... Get an LP and imaging ... node biopsy • Clinical ... Bone marrow biopsy ... #diagnosis
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Phosphatase Of Clinical ... Most cases diagnosed ... • Pernicious anemia ... mineralization Symptoms ... Phosphatase: • Other causes