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Acyclovir - Pharmacology Summary • Mechanism of Action: Nucleoside analog - selectively inhibits viral replication of
Acyclovir - Pharmacology ... Nucleoside analog - selectively ... TheIDtrivia #Acyclovir
NSAID Selectivity Spectrum COX-2 Selective NSAID - Celecoxib • Increased risk for CV events • Decreased risk
NSAID Selectivity ... effects #NSAIDs #selectivity
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 Urine Microscopy - Kidney Stones and Crystals Uric Acid, Cystine, Hippurate, Cloth Fiber, Tyrosine, CaOx, CaP,
CaCO3, Struvite, Acyclovir ... Identification #Differential
The algorithm below shows how pre-test probability could be combined with various criteria to determine which
require empiric acyclovir ... The risk of acyclovir-induced ... favor the use of acyclovir ... -Acyclovir is nephrotoxic ... require empiric acyclovir
Drug Induced Kidney Injury • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy • Osmotic
Methotrexate, Orlistat, Acyclovir ... #KidneyInjury #differential
Medications causing Acute Kidney Injury (AKI) Prerenal: • Dehydration: Diuretics • Altered intrarenal autoregulation: ACEIs / ARBs,
Crystal nephropathy: Acyclovir ... #pharmacology #differential
Varicella (Chickenpox) - Crops of vesicles in various stages of healing Treatment • Healthy g 12
Immunocompromised or > 12: Acyclovir
Heparin and Low Molecular Weight Heparin (LMWH)–Mediated Inactivation of Thrombin or Factor Xa - Interaction
- LMWH selectively
Antibiotics and CNS Diffusion 1. Drugs with good CNS diffusion: - Fluoroquinolones, Fluconazole, voriconazole, Rifampin, Oxazolidinones, Metronidazole 2. Drugs
β-lactam agents, Aciclovir
NSAIDS and COX Selectivity Relative selectivity of some commonly used NSAIDs. Data shown as the logarithm of
NSAIDS and COX Selectivity ... Relative selectivity ... COX-1 Selectivity ... Fenoprofen COX-1 Selectivity ... #pharmacology #selectivity
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