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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic Lupus ... Microangiopathies #Systemic #Lupus ... Erythematosus #SLE ... #hematology #rheumatology ... #differential #diagnosis
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
- Differential Diagnosis ... Bullous systemic lupus ... tarda • Diabetic ... Vesiculobullous #SkinRash ... #dermatology #Differential
Skin Ulcers of the Lower Legs / Feet - Differential Diagnosis Algorithm
Physical:
• Pressure
• Trauma
• Radiation
Vascular:
• Arterial
- Differential Diagnosis ... Neurological: • Diabetic ... gangrenosum • Diabetic ... Ulcers #ulcerative #skinrash ... #dermatology #Differential
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... permeability Diagnosis ... Induction Rx: high-dose ... Erythematosus #SLE ... #CNS #neurology
Lupus Nephritis Primer
Class I - Minimal Mesangial
Class II - Mesangial Proliferative
Class Ill - Focal Proliferative
Class IV
Lupus Nephritis ... DrFlashHeart #Lupus ... #Nephritis #SLE ... #differential #diagnosis ... #management #nephrology
Necrotizing Fasciitis: Note the extensive edema, erythema, bullae formation, and necrosis in this patient's thigh. At
this patient's thigh ... presentation, this diabetic ... Clinical #Photo #Dermatology ... #SkinRash #Necrotizing
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... • Specific for SLE ... Severe disease- high ... #Systemic #Lupus ... #Summary #diagnosis
Sarcoidosis - Skin Manifestations

This is a quick overview of some of the cutaneous manifestations of sarcoidosis.
Sarcoid Plaques • Lupus ... #Sarcoidosis #diagnosis ... treatment #photo #dermatology ... #skinrash
Skin Ulcers by Etiology - Differential Diagnosis Algorithm
Physical:
 • Trauma
 • Pressure
 • Radiation
Vascular:
 • Arterial
- Differential Diagnosis ... Neurological: • Diabetic ... gangrenosum • Diabetic ... Ulcers #ulcerative #skinrash ... #dermatology #Differential
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
- Differential Diagnosis ... • Nephrogenic diabetes ... #Differential #Diagnosis ... #Causes #nephrology ... #sodium #high