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diagnosis hematology differential management classification druginduced erythematosus symptoms syndrome systemic algorithm antiphospholipid apls behcet chronic cll comparison cryofibrinogenemia cryoglobulinemia cryoglobulins
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
: • Vascular occlusion ... Associated - SLE ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... 40, F:M 9:1 • Clinical ... • Immunologic Workup ... Positive in 60-80% of cases ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... • Immunologic Workup ... 40, F:M 9:1 • Clinical ... • Immunologic Workup ... #table #rheumatology
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... disease (10%) : SLE ... #dermpath #dermatology ... #semiology #signs ... lesions #diagnosis #clinical
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... (SLE) General: ... Butterfly rash, Vasculitis ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... reactions, and vaso-occlusive ... purpura: strong sign ... , and SLE) • Urinalysis ... differential #diagnosis #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Syndrome: • Clinical ... (e.g. systemic lupus ... classification #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
disease (SVC/IVC occlusion ... Oral aphthae : SLE ... • Arthritis: SLE ... diagnosis #management #signs ... #symptoms #rheumatology
When to look for clonal/neoplastic hypereosinophilia (HEo)? - Exclusion of frequent causes (Drug-induced HEo, helminthiasis, cancer,
- Exclusion of frequent ... causes (Drug-induced ... ) - Clinical symptoms ... HEON #Diagnosis #Signs ... #Hematology #Workup
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
malignancies, vasculitis ... and/or venous occlusions ... cryoglobulins • Negative causes ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
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