13 results
Allopecia - Differential Diagnosis Framework for Hair Loss

Localized / Focal Hair Loss Pattern:
 • Scarring Alopecia:
Capitis - Skin ... , Loose anagen syndrome ... Examination: • Signs ... Vitamin D levels Systemic ... Differential #Diagnosis #dermatology
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... response -> Subacute cutaneous ... areas -> Scaring alopecia ... inflammation on skin ... pathophysiology #diagnosis #signs
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... Sjögrens (15%) Skin ... Demyelinating syndromes ... #SLE #systemic ... erythematosus #signs
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... and permanent alopecia ... • Nonscarring alopecia ... #Systemic #Lupus
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
(PBC), or with systemic ... arthritis (RA) or systemic ... lupus erythematosus ... (SLE) Signs / ... Xeroderma (Dry skin
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
associated with systemic ... Most common extra cutaneous ... Episcleritis Signs ... - Lupus - Leukemia ... #diagnosis #dermatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
aphthous ulcers, cutaneous ... lupus erythematosus ... reactions, and vaso-occlusive ... purpura: strong sign ... vasculitis, and SLE
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Systemic disease ... vasculitis) • Cutaneous ... disease (SVC/IVC occlusion ... Oral aphthae : SLE ... diagnosis #management #signs
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... - Purpura - Skin ... reticularis & skin ... Henoch-Schönlein purpura) • Cutaneous ... lupus erythematosus
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Alpha & Mu) Skin ... gangrenosum • Cutaneous ... thrombosis+Pulm HTN+skin ... to cold IgG • Lupus ... Paraproteinemias #Hematology