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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic Lupus ... Erythematosus #SLE ... #hematology #rheumatology ... #differential # ... diagnosis #causes
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Malar rash • SLE ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #rashes #differential
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... severe disease & renal ... Associated with skin ... severe disease Treatment ... #Systemic #Lupus
Mucous Membrane Disorder - Differential Diagnosis Algorithm
Erosions/Ulcers/Blisters
 - Primary Dermatologic Diseases
     •
Membrane Disorder - Differential ... Stevens-Johnson Syndrome ... • Systemic lupus ... #Differential # ... Diagnosis #Algorithm #causes
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Systemic and Primary Causes ... BUN: • Chronic renal ... Myelodisplastic syndrome ... #generalized #dermatology ... Diagnosis #Algorithm #causes
Genital Skin Ulcers - Differential Diagnosis Algorithm
Painful:
 • Herpes simplex
 • Haemophilus ducreyi (chancroid)
 • Behcet's
Genital Skin Ulcers ... - Differential ... ) • Behcet's syndrome ... ulcerative #skinrash #dermatology ... Diagnosis #Algorithm #causes
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
Vesiculobullous Skin ... Rash - Differential ... Bullous systemic lupus ... Vesiculobullous #SkinRash #dermatology ... Diagnosis #Algorithm #causes
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... autoantibodies that will cause ... Puncture, EEG Treatment ... Erythematosus #SLE
Hypertension and Altered Mental Status (AMS) - Differential Diagnosis Framework

Hypertension:
 • Hypertensive emergency
 • Hypertensive encephalopathy
Status (AMS) - Differential ... • Cushing’s syndrome ... Vasculitis • Lupus ... • Serotonin syndrome ... #Diagnosis #causes
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
most frequent skin ... dermatomyositis, SLE ... #differential # ... diagnosis #dermatology ... oncology #clinical #skin