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diagnosis hematology management differential oncology erythematosus systemic vasculitis classification leukemia activation anca anemia antibodies antibody antinuclear antinxp2 antinxp2dm aplastic behcet
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
(Antineutrophil ... ) • Systemic lupus ... in drug-induced SLE ... • Sjögren syndrome ... antibodies #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Antinuclear (ANA ... severe disease & renal ... Associated with skin ... severe disease Treatment ... Summary #diagnosis #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... autoantibodies that will cause ... Erythematosus #SLE ... CNS #neurology #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... - Purpura - Skin ... DDX: • ANCA (Antineutrophil ... (e.g. systemic lupus ... classification #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... Non-autoimmune rheumatologic ... Seizures • Strokes Skin ... APLA/LAC: • Renal
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... Kasabach-Merritt syndrome ... Associated - SLE ... Differential #Diagnosis #hematology ... #rheumatology #
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... antiphospholipid syndrome ... S - Systemic Lupus ... Ann Marie Kumfer ... #differential #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
damage) • Skin ... Oral aphthae : SLE ... • Arthritis: SLE ... Arthritis, AS Treatment ... signs #symptoms #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
SJIA], systemic lupus ... erythematosus [SLE ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
) is a skin condition ... Causes: - Idiopathic ... - Lupus - Leukemia ... Treatment: - Systemic ... #diagnosis #dermatology
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