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rheumatology differential secondary erythematosus hematology management syndrome classification clinical generalized oncology pruritus rash signs symptoms ana anca antibodies antibody antineutrophil
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... Sjögrens (15%) Skin ... Butterfly rash, Vasculitis ... #SLE #systemic ... signs #symptoms #diagnosis
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... severe disease & renal ... Associated with skin ... severe disease Treatment ... diagnosis #rheumatology
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions - Inflammatory
Vesiculobullous Skin ... • Bullous systemic ... lupus erythematous ... Vesiculobullous #SkinRash #dermatology ... #Algorithm #causes
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Algorithm - Systemic ... and Primary Causes ... BUN: • Chronic renal ... #generalized #dermatology ... #Algorithm #causes
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... tract, and often causes ... inflammation Others: • Lupus ... lupus erythematosus ... , and SLE) • Urinalysis
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... ASA) • Renal Disease ... • Steroids • Vasculitis ... #Algorithm #Causes ... #Hematology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
antibodies) • Systemic ... lupus erythematosus ... in drug-induced SLE ... vasculitis - MPO ... Antineutrophil #antibodies #diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • They can cause ... - Purpura - Skin ... Cryoglobulins Cause ... lupus erythematosus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... Differential Diagnosis ... Seizures • Strokes Skin ... #Systemic #Lupus
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Abnormality • SLE ... discoloration) • Chronic renal ... #Secondary #dermatology ... #Differential #Diagnosis ... #Algorithm #causes
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