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diagnosis rheumatology classification differential syndrome hematology symptoms activation behcet causes cerebritis cns comparison druginduced eularacr hemeonc hemophagocytic hlh hyperkalemia lymphohistiocytosis
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... & renal involvement ... - high dose steroid ... #Lupus #Erythematosus ... #rheumatology #management
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... Lupus Erythematosus ... #SLE #Systemic ... #Lupus #Erythematosus
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... disease (30%): ... #SLE #systemic ... #erythematosus # ... signs #symptoms
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Lupus Erythematosus ... Cerebrovascular Disease ... Induction Rx: high-dose ... #Lupus #Erythematosus ... cerebritis #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... complements and a high ... lupus erythematosus ... APLA/LAC: • Renal ... #Systemic #Lupus
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... lupus erythematosus ... [SLE], AOSD) • ... Histopathologic criteria ... Syndrome #Diagnosis #Management
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Immune Complex: Systemic ... lupus erythematosus ... Rheumatoid arthritis, Systemic ... • Labs: CBC, cr ... infiltrates) → high
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
thiazidic, PPI, ACE ... months to years) Systemic ... Lupus Erythematosus ... Usual therapeutic management ... : Chronic disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... ischemia - Skin: erythematous ... lupus erythematosus ... purpura: strong sign ... vasculitis, and SLE
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome Systemic ... Oral aphthae : SLE ... exacerbations: high-dose ... Syndrome #diagnosis #management ... #signs #symptoms
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