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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic ... Lupus Erythematosus ... #Lupus #Erythematosus ... #SLE #hematology ... differential #diagnosis #causes
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Photosensitivity, Alopecia ... • Immunologic Workup ... Positive in 60-80% of cases ... #lupus #Systemic
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms
Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
Systemic Lupus Erythematosus ... (SLE) - Typical ... Signs/Symptoms ... Alopecia, Fever, ... #SLE #Signs #Symptoms
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
: Non-scarring alopecia ... pericarditis • Hematologic ... hemolysis • Renal ... Classification #Criteria #SLE ... #Systemic #Lupus
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Discontinuation of causal ... months to years) Systemic ... Photosensitivity, Alopecia ... • Immunologic Workup
Allopecia - Differential Diagnosis Framework for Hair Loss

Localized / Focal Hair Loss Pattern:
 • Scarring Alopecia:
Disease: Discoid lupus ... : Lupus erythematosus ... Examination: • Signs ... Vitamin D levels Systemic ... Differential #Diagnosis #dermatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... Abdominal pain (20%) Renal ... Thrombocytopenia #Lupus ... #SLE #systemic ... erythematosus #signs
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... Criteria - Systemic ... - NON-SCARRING ALOPECIA ... - SEROSITIS - RENAL ... #SLE #Lupus #Erythematosus
Drug Reaction with Eosinophilia and Systemic Signs (DRESS Syndrome): Formerly known as drug hypersensitivity reaction, DRESS
represents
Eosinophilia and Systemic ... Signs (DRESS Syndrome ... medication (in this case ... Images #Clinical #Dermatology ... Eosinophilia #Legs #Photo
Drug Reaction with Eosinophilia and Systemic Signs (DRESS Syndrome): Formerly known as drug hypersensitivity reaction, DRESS
represents
Eosinophilia and Systemic ... Signs (DRESS Syndrome ... medication (in this case ... Images #Clinical #Dermatology ... Eosinophilia #Photo