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diagnosis rheumatology differential erythematosus management ana anca antibodies antibody antineutrophil antinuclear classification clinical comparison cutaneous diseases druginduced eschar hair hairloss
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Photosensitivity, Alopecia ... • Immunologic Workup ... Positive in 60-80% of cases ... #lupus #Systemic
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... Butterfly rash, Vasculitis ... Abdominal pain (20%) Renal ... #SLE #systemic ... erythematosus #signs
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... months to years) Systemic ... Photosensitivity, Alopecia ... • Immunologic Workup ... #table #rheumatology
Allopecia - Differential Diagnosis Framework for Hair Loss Localized / Focal Hair Loss Pattern: • Scarring Alopecia:
Disease: Discoid lupus ... : Lupus erythematosus ... Examination: • Signs ... Vitamin D levels Systemic ... Differential #Diagnosis #dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... and permanent alopecia ... Malignancy (e.g. hematologic ... • Nonscarring alopecia ... #Systemic #Lupus
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
antibodies) • Systemic ... lupus erythematosus ... in drug-induced SLE ... ) • Systemic sclerosis ... vasculitis - MPO
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... inflammation Others: • Lupus ... lupus erythematosus ... purpura: strong sign ... , and SLE) • Urinalysis
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Episcleritis Signs ... Causes: - Idiopathic ... , breast CA - Hematologic ... ’s syndrome - Lupus ... Syndrome #diagnosis #dermatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
pulmonary and renal ... diseases, such as SLE ... purpura: Strong sign ... tract, and often causes ... Differential #Diagnosis #Rheumatology
Cutaneous Mucormycosis Eschar 30 M HIV cd4 10 VL 30k traumatic injury of arm few months ago
drug injections, renal ... malnutrition, HIV, SLE ... wide excision & systemic ... Mucormycosis #Eschar #dermatology ... skin #clinical #photo
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