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diagnosis rheumatology hematology differential erythematosus gammopathy significance signs vasculitis behcet chronic cll complications criteria cryoglobulinemia cryoglobulins disease eularacr leukemia lymphocytic
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
of Clinical Significance ... Cryoglobulinemia Renal-centered ... #Gammopathy #Clinical ... Differential #Diagnosis #hematology ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Can Feature A Monoclonal ... to cold IgG • Lupus ... , retinal, DVT, ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Significance (MGUS ... constitutional symptoms ... hyperCalcemia, Renal ... #Significance #hematology ... #diagnosis #oncology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... of Systemic Lupus ... (SLE) General: ... #SLE #systemic ... erythematosus #signs #symptoms
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... Clinical Domains ... #Criteria #SLE ... #Systemic #Lupus
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Significance (MGUS ... treatment of infective symptoms ... ; vaccinations Renal ... rituximab (in clinical ... high-risk situations #MGUS
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... Skin Disease Classification ... : • Symptoms limited ... #Systemic #Lupus
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Syndrome: • Clinical ... lupus erythematosus ... (SLE), rheumatoid ... diagnosis #types #classification
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome Systemic ... association • M > F Clinical ... Oral aphthae : SLE ... • Arthritis: SLE ... refractory disease : monoclonal
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... lupus erythematosus ... Symptoms (Sx) in ... vasculitis, and SLE ... #rheumatology #classification
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