49 results
Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
in Systemic Lupus ... #diseases #SLE ... #Systemic #Lupus ... venn #nephrology #nephritis ... classification #types #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... nephritis, NPSLE ... • Immunologic Workup ... : - ANA > ... Management #Summary #rheumatology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
Antinuclear Antibody (ANA ... Arthritis R Renal ... Disease (Nephritis ... #IMDAMNSHARP #sle ... erythematosus #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... findings (ANA, ... Non-autoimmune rheumatologic ... Arthritis: • Joint pain ... APLA/LAC: • Renal
Algorithm for the Treatment of Membranous Lupus Nephritis
Sub-nephrotic-range proteinuria (<3.5g/d, normal serum albumin) and Preserved kidney
of Membranous Lupus ... serum albumin) and ... SLE 4. ... SLE • Calcineurin ... #Membranous #Lupus
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... : - ANA > ... nephritis, NPSLE ... : - ANA > ... #table #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
hemolysis • Renal ... nephritis, Class ... low C4, Low C3 and ... Classification #Criteria #SLE ... Erythematosus #diagnosis #rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Systemic lupus ... lupus nephritis ... , neonatal lupus ... erythematosus #diagnosis #rheumatology ... #table #ANA
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Malar rash • SLE ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #joint #pain #skin ... differential #diagnosis #rheumatology
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
Management of Lupus ... Nephritis Lupus ... in 10 to 40% of SLE ... or 0.5 g/day → renal ... treatment #management #rheumatology