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diagnosis differential algorithm alopecia hairloss symptoms diffuse hematology manifestations pathophysiology rheumatology anca antibodies antibody antineutrophil bone chronic classification cll common
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... (SLE): Musculoskeletal ... Myopathy (Also caused ... #Complications ... pathophysiology #signs
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
erythematosus ... • Discoid lupus ... erythematosus ... HairLoss #Alopecia #dermatology ... Diagnosis #Algorithm #causes
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... inflammation onto hair ... follicles -> causes ... pathophysiology #diagnosis #signs ... #symptoms #complications
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... ) • Systemic lupus ... erythematosus ... in drug-induced SLE ... #Antinuclear #Antibody
Allopecia - Differential Diagnosis Framework for Hair Loss Localized / Focal Hair Loss Pattern: • Scarring Alopecia:
Disease: Discoid lupus ... erythematosus, ... erythematosus, ... Examination: • Signs ... Differential #Diagnosis #dermatology
Papulosquamous Skin Rash - Differential Diagnosis Algorithm Erythrematous or violaceous papules & plaques with overlying scale •
Auspitz sign, Koebner's ... soles • Discoid Lupus ... Erythematous - ... Papulosquamous #SkinRash #dermatology ... Diagnosis #Algorithm #causes
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
other orthopedic complications ... XR, MRI to dx and ... dz difficult to see ... • Hematogenous ... #hematology
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
involvement: Intractable nausea ... pain • Extra-CNS complications ... disorders (Systemic lupus ... erythematosus, ... neurology #symptoms #signs
Diffuse Hair Loss (Alopecia) - Differential Diagnosis Algorithm Scarring - Irreversible-biopsy required • Lupus erythematosus • Lichen
Irreversible-biopsy required • Lupus ... erythematosus ... totalis (all scalp and ... HairLoss #Alopecia #dermatology ... Diagnosis #Algorithm #causes
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... such as systemic lupus ... erythematosus, ... purpura: strong sign ... SLE) • Urinalysis
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