14 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... (SLE): Musculoskeletal ... #Lupus #Erythematosus ... #SLE #MSK #Musculoskeletal ... Complications #pathophysiology
Systemic Lupus Erythematosus (SLE): Pathogenesis

 • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... (SLE): Pathogenesis ... Abnormal release of inflammatory ... #Lupus #Erythematosus ... #SLE #Pathophysiology
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
psoriasis (7-30%) • Inflammatory ... Lupus - with Systemic ... Lupus Erythematosus ... (SLE), should have ... Joint #Disorders #msk
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... (SLE) Clinical ... Disease, PRES Pathophysiology ... Treatment: • Inflammatory ... #SLE #CNS #neurology
Inflammatory Joint Pain - Differential Diagnosis Algorithm 
Monoarticular
 • Gout (Podagra, Tophi)
 • Pseudogout
 • Early
Inflammatory Joint ... bite, Migratory red ... Arthritis • Systemic ... Lupus Erythematosus ... #JointPain #MSK
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... cytokines -> localized inflammatory ... Scaring alopecia • Red ... #SLE #Mucocutaneous ... Manifestations #pathophysiology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... photosensitivity, inflammatory ... Female • Peaks 3rd ... Skin Disease Classification ... #Systemic #Lupus
Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
heat and looks red ... is oftentimes systemic ... Rheumatoid arthritis, Lupus ... Comparison #Versus #MSK ... JointPain #Diagnosis #pathophysiology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
background of a highly inflammatory ... release of pro-inflammatory ... lupus erythematosus ... lupus erythematosus ... [SLE], AOSD) •
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
- Red blood cell ... activation provides inflammatory ... lupus erythematosus ... Hypersensitivity #Types #Classification ... #Pathophysiology