11 results
Renal involvement in Systemic Lupus Erythematosus (SLE)

Dr. Laurent ARNAUD @Lupusreference

#Renal #lupus #nephritis #SLE #Systemic #Erythematosus #SLE
Renal involvement ... in Systemic Lupus ... #lupus #nephritis ... #SLE #Systemic ... #management #treatment
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
Causes of Acute ... at least 50% Renal ... Drugs • Emboli Systemic ... Acute Interstitial Nephritis ... Sjögren) Post-Renal
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... and Management ... nephritis, NPSLE ... Positive in 60-80% of cases ... #lupus #Systemic
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Female • Peaks 3rd ... APLA/LAC: • Renal ... Chronic B-cell activation ... #Systemic #Lupus
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
Common causes of ... Kidney Injury AKI ... Secondary GNs: Due to systemic ... Post-infectious GN, Lupus ... Acute Interstitial Nephritis
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Abnormality • SLE ... discoloration) • Chronic renal ... discoloration) • Nephrotic ... #Secondary #dermatology ... Diagnosis #Algorithm #causes
Acute Kidney Injury - Differential Diagnosis Framework
PRERENAL:
 - Intrarenal vasoconstriction-hemodynamically mediated
 - Systemic vasodilation
 - Volume
vasoconstriction-hemodynamically mediated - Systemic ... - Glomerular (red ... biopsy - Management ... treating underlying cause ... Kidney #Injury #AKI
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... months to years) Systemic ... nephritis, NPSLE ... Usual therapeutic management ... rheumatology #diagnosis #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... lupus erythematosus ... lupus erythematosus ... [SLE], AOSD) • ... Syndrome #Diagnosis #Management
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... cirrhosis: 3%-20% Renal ... • Interstitial nephritis ... Distal (Type I) renal ... Rheumatology #Diagnosis #Management