11 results
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
the cause: • Systemic ... Lupus • Erythematosus ... (SLE) If bacterial ... the cause: • Arthritis ... #Immunology #pathophysiology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... of hip (rare), Arthritis ... #SLE #systemic
SOAP BRAIN MD Mnemonic for Systemic Lupus Erythematosus (SLE)

S - Serositis (Pleuritis, Pericarditis)
O - Oral Ulcers
A
MD Mnemonic for Systemic ... Lupus Erythematosus ... Oral Ulcers A - Arthritis ... A - ANA I - Immunologic ... Neuropsychiatric Symptoms
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
- with the skin ... Lupus - with Systemic ... (SLE), should have ... other symptoms ... like “butterfly rash
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... , Arthritis, myalgia ... NPSLE rare, Malar rash ... constitutional symptoms ... months to years) Systemic
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
like rheumatoid arthritis ... lupus erythematosus ... (SLE) Signs / ... Xeroderma (Dry skin ... Sjogrens #Syndrome #Pathophysiology
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
sudden onset of a rash ... - Rash: multiple ... CANDLE syndrome - Allergic ... ’s syndrome - Lupus ... Syndrome #diagnosis #dermatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Female • Peaks 3rd ... Decade Skin ... : • Symptoms limited ... #Systemic #Lupus
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Scaring alopecia • Red ... inflammation on skin ... Manifestations #pathophysiology ... diagnosis #signs #symptoms
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
inflammation Others: • Lupus ... mucositis - Rash ... lupus erythematosus ... Symptoms (Sx) in ... vasculitis, and SLE