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Cutaneous Manifestations of Monoclonal Gammopathy • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
Extravascular lg Deposits ... hyperkeratotic spicules ... Intravascular lg deposits
Xanthelasma: Yellow deposits apparent above and below eyes, due to infiltration with fat laden cells. This
Xanthelasma: Yellow deposits ... Photo courtesy of ... Images #Clinical #Photo
This image shows spicular amyloid with tapering conical masses interconnected by branching fibrils! Dr. Stephen Bonsib via
This image shows spicular ... arkanalabs #amyloid #spicular ... #desposition #deposits
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 Nephrotic Syndrome - Classification - Podocytopathies - Immunocomplex Deposits - Other substances Deposits #Nephrotic #Syndrome
Immunocomplex Deposits ... Other substances Deposits
This image shows spicular amyloid deposits showing blunt conical formations with interconnecting fibrils. Dr. Stephen Bonsib via
This image shows spicular ... amyloid deposits ... arkanalabs #amyloid #deposits
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 Aneurysm Morphology Types - Fusiform Aneurysm - Saccular Aneurysm - Ruptured Aneurysm #vascular #Aneurysm
Fusiform Aneurysm - Saccular ... Types #Fusiform #Saccular
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
glomerulopathy (Dense deposit ... Minimal immune deposits
Diabetic Retinopathy: Pathogenesis and clinical findings Mild Non-proliferative DR • Outpouchings of the weakened capillary walls or
• Yellow lipid deposits ... Focal areas of saccular
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
Presence of immune deposits ... on IF • No EM deposits ... Minimal immune deposits
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
• Organized Ig deposits ... Non-organized Ig deposits ... monoclonal Ig deposits ... gammopathy • (-) Ig deposits
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