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Cutaneous Manifestations of Monoclonal Gammopathy • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
Extravascular lg Deposits ... hyperkeratotic spicules ... Intravascular lg deposits
This image shows spicular amyloid with tapering conical masses interconnected by branching fibrils! Dr. Stephen Bonsib via
This image shows spicular ... arkanalabs #amyloid #spicular ... #desposition #deposits
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 This image shows spicular amyloid deposits showing blunt conical formations with interconnecting fibrils. Dr. Stephen Bonsib via
This image shows spicular ... amyloid deposits ... arkanalabs #amyloid #deposits
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 This image shows portions of glomerular tuft with collapsed GBM (across top), spicular amyloid (middle right),
(across top), spicular ... #desposition #deposits
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 Nephrotic Syndrome - Classification - Podocytopathies - Immunocomplex Deposits - Other substances Deposits #Nephrotic #Syndrome
Immunocomplex Deposits ... Other substances Deposits
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
glomerulopathy (Dense deposit ... Minimal immune deposits
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
Presence of immune deposits ... on IF • No EM deposits ... Minimal immune deposits
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
• Organized Ig deposits ... Non-organized Ig deposits ... monoclonal Ig deposits ... gammopathy • (-) Ig deposits
Hydroxyapatite Deposition Disease (HADD) - MSK Radiology Imaging Findings: • Ovoid hypointense structures along the bursal surface
Hydroxyapatite deposits ... Hydroxyapatite deposits ... - Deposits ... Hydroxyapatite deposits
Diagnosis of IgA Vasculitis (Henoch-Schönlein Purpura) - French Vasculitis Study Group 1) Suggestive clinical manifestations
dominant immune deposits ... - Dominant IgA deposits ... with vascular IgA deposits
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