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diagnosis hematology management hemophagocytic hlh infections infectiousdiseases lymphohistiocytosis table aids coagulation cryofibrinogenemia differential disseminated druginduced fungal hemeonc hiv intravascular leukemia
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
organ damage Clinical ... Thromboembolism (7%) • CNS ... : • Treat primary ... cause • Correct ... #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... 40, F:M 9:1 • Clinical ... life-threatening • Treatment ... druginduced #lupus #sle #comparison ... #table #rheumatology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
encephalitis, and primary ... should be based on clinical ... Antimicrobial treatment ... Demyelinating disease caused ... Syphilis • Aspergillosis
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
Risk factors: Critical ... without other cause ... : 33% • Treatment ... Transfusion #Reactions #hematology ... #diagnosis #comparison
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... Diagnosis: • Histoplasma ... has five major clinical ... especially the CNS ... MC: CNS CSF: •
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Primary (essential ... Diagnosis: • + Clinical ... cryoglobulins • Negative causes ... skin necrosis • DIC ... #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... salivary ducts Clinical ... • Nephrogenic DI ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
Lymphohistiocytosis (HLH) Treatment ... Primary HLH: - ... (depending on CNS ... autoimmune disease, treatment ... #management #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... -> AML: Blast crises ... + distinctive primary ... Fibrinolysis & DIC ... #Leukemia #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
HLH is a critical ... hyperinflammatory syndrome caused ... Types of HLH • Primary ... Clinical Presentation ... Diagnosis #Management #Hematology
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